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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
17/01/2017 |
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Data da última atualização: |
22/02/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; FRITZ-WATERS, E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. |
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Afiliação: |
ALINE SILVA MELLO CESAR, USP, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; MIRELE DAIANA POLETI, USP; SÓNIA CRISTINA DA SILVA ANDRADE, USP; POLYANA CRISTINE TIZIOTO, CPPSE; PRISCILA SILVA NEUBERN DE OLIVEIRA, CPPSE; ANDREZZA MARIA FELÍCIO, USP; MICHELE LOPES DO NASCIMENTO, USP; AMALIA SATURNINO CHAVES, USP; DANTE PAZZANESE DUARTE LANNA, USP; RYMER RAMIZ TULLIO, CPPSE; RENATA TIEKO NASSU, CPPSE; JAMES EUGENE KOLTES, University of Arkansas; ERIC FRITZ-WATERS, University of Arkansas; GERSON BARRETO MOURÃO, USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUIZ LEHMANN COUTINHO, USP. |
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Título: |
Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
BMC Genomics, London, v. 17, p. 1-16, 2016. |
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DOI: |
10.1186/s12864-016-3306-x |
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Idioma: |
Inglês |
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Conteúdo: |
Background: Lipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle. Results: Skeletal muscle transcriptome analysis of 164 Nellore steers revealed no differentially expressed genes (DEGs, FDR 10%) for samples with extreme values for linoleic acid (LA) or stearic acid (SA), and only a few DEGs for eicosapentaenoic acid (EPA, 5 DEGs), docosahexaenoic acid (DHA, 4 DEGs) and palmitic acid (PA, 123 DEGs), while large numbers of DEGs were associated with oleic acid (OA, 1134 DEGs) and conjugated linoleic acid cis9 trans11 (CLA-c9t11, 872 DEGs). Functional annotation and functional enrichment from OA DEGs identified important genes, canonical pathways and upstream regulators such as SCD, PLIN5, UCP3, CPT1, CPT1B, oxidative phosphorylation mitochondrial dysfunction, PPARGC1A, and FOXO1. Two important genes associated with lipid metabolism, gene expression and cancer were identified as DEGs between animals with high and low CLA-c9t11, specifically, epidermal growth factor receptor (EGFR) and RNPS. Conclusion: Only two out of seven classes of molecules of FA studied were associated with large changes in the expression profile of skeletal muscle. OA and CLA-c9t11 content had significant effects on the expression level of genes related to important biological processes associated with oxidative phosphorylation, and cell growth, survival, and migration. These results contribute to our understanding of how some FAs modulate metabolism and may have protective health function. MenosBackground: Lipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle. Results: Skeletal muscle transcriptome analysis of 164 Nellore steers revealed no differentially expressed genes (DEGs, FDR 10%) for samples with extreme values for linoleic acid (LA) or stearic acid (SA), and only a few DEGs for eicosapentaenoic acid (EPA, 5 DEGs), docosahexaenoic acid (DHA, 4 DEGs) and palmitic acid (PA, 123 DEGs), while large numbers of DEGs were associated with oleic acid (OA, 1134 DEGs) and conjugated linoleic acid cis9 trans11 (CLA-c9t11, 872 DEGs). Functional annotation and functional enrichment from OA DEGs identified important genes, canonical pathways and upstream regulators such as SCD, PLIN5, UCP3, CPT1, CPT1B, oxidative phosphorylation mitochondrial dysfunction, PPARGC1A, and FOXO1. Two important genes associated with lipi... Mostrar Tudo |
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Palavras-Chave: |
Global oxidative metabolism. |
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Thesagro: |
Bos Indicus. |
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Thesaurus Nal: |
Cattle; Gene expression; Human Health; Lipids; Sequence analysis; Zebu. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03391naa a2200433 a 4500
001 2060888
005 2017-02-22
008 2016 bl uuuu u00u1 u #d
024 7 $a10.1186/s12864-016-3306-x$2DOI
100 1 $aCESAR, A. S. M.
245 $aDifferences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content.$h[electronic resource]
260 $c2016
520 $aBackground: Lipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle. Results: Skeletal muscle transcriptome analysis of 164 Nellore steers revealed no differentially expressed genes (DEGs, FDR 10%) for samples with extreme values for linoleic acid (LA) or stearic acid (SA), and only a few DEGs for eicosapentaenoic acid (EPA, 5 DEGs), docosahexaenoic acid (DHA, 4 DEGs) and palmitic acid (PA, 123 DEGs), while large numbers of DEGs were associated with oleic acid (OA, 1134 DEGs) and conjugated linoleic acid cis9 trans11 (CLA-c9t11, 872 DEGs). Functional annotation and functional enrichment from OA DEGs identified important genes, canonical pathways and upstream regulators such as SCD, PLIN5, UCP3, CPT1, CPT1B, oxidative phosphorylation mitochondrial dysfunction, PPARGC1A, and FOXO1. Two important genes associated with lipid metabolism, gene expression and cancer were identified as DEGs between animals with high and low CLA-c9t11, specifically, epidermal growth factor receptor (EGFR) and RNPS. Conclusion: Only two out of seven classes of molecules of FA studied were associated with large changes in the expression profile of skeletal muscle. OA and CLA-c9t11 content had significant effects on the expression level of genes related to important biological processes associated with oxidative phosphorylation, and cell growth, survival, and migration. These results contribute to our understanding of how some FAs modulate metabolism and may have protective health function.
650 $aCattle
650 $aGene expression
650 $aHuman Health
650 $aLipids
650 $aSequence analysis
650 $aZebu
650 $aBos Indicus
653 $aGlobal oxidative metabolism
700 1 $aREGITANO, L. C. de A.
700 1 $aPOLETI, M. D.
700 1 $aANDRADE, S. C. da S.
700 1 $aTIZIOTO, P. C.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aFELICIO, A. M.
700 1 $aNASCIMENTO, M. L. do
700 1 $aCHAVES, A. S.
700 1 $aLANNA, D. P. D.
700 1 $aTULLIO, R. R.
700 1 $aNASSU, R. T.
700 1 $aKOLTES, J. E.
700 1 $aFRITZ-WATERS, E.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aREECY, J. M.
700 1 $aCOUTINHO, L. L.
773 $tBMC Genomics, London$gv. 17, p. 1-16, 2016.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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| Registros recuperados : 11 | |
| 1. |  | PÉRTILLE, F.; ZANELLA, R.; FELÍCIO, A. M.; LEDUR, M. C.; PEIXOTO, J. de O.; COUTINHO, L. L. Identification of polymorphisms associated with production traits on chicken (Gallus gallus) chromosome 4. Genetics and Molecular Research, v. 14, n. 3, p. 10717-10728, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 2. | | FELÍCIO, A. M.; BOSCHIERO, C.; SILVA, N. A.; LEDUR, M. C.; JORGE, E. C.; COUTINHO, L. L. Identificação de polimorfismos nos genes MC4R, FGFBP1 e FGFBP2 em galinhas. In: CONGRESSO BRASILEIRO DE GENÉTICA, 56., 2010. Resumos. Guarujá: SBG , 2010. p. 80. Projeto/Plano de Ação: 01.06.10.602-02.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 3. | | OLIVEIRA, G. B. de; CESAR, A. S. M.; FELÍCIO, A. M.; KAPPELER, B. I. G.; POLETI, M. D.; REGITANO, L. C. de A.; COUTINHO, L. L. Evidence of miRNA regulation of intramuscular fat deposition in beef cattle. In: PLANT AND ANIMAL GENOME CONFERENCE, 24., 2016, San Diego. Anais... San Diego: PAG, 2016.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 4. | | OLIVEIRA, G. B. de; CESAR, A. S. M.; FELICIO, A. M.; POLETI, M. D.; REGITANO, L. C. de A.; COUTINHO, L. L. Gene network regulated by microRNAs suggests modulation of fat deposition in cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 5. | | PÉRTILLE, F.; FELÍCIO, A. M.; ROSÁRIO, M. F. do; SILVA, V. H.; MANGUETTI, T.; SILVA, N. A.; LEDUR, M. C.; COUTINHO, L. L. PPARGC1A indel polymorphism is associated with performance and carcass traits in chickens. In: CONGRESSO BRASILEIRO DE GENÉTICA, 58., 2012, Foz do Iguaçu. Resumos... Foz do Iguaçú: SBG, 2012. p. 72| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 6. | | FELÍCIO, A. M.; BOSCHIERO, C.; BALIEIRO, J. C. C.; LEDUR, M. C.; FERRAZ J. B. S.; MICHELAN FILHO, T.; MOURA, A. S. A. M. T.; COUTINHO, L. L. Identification and association of polymorphisms in CAPN1 and CAP3 candidate genes related to performance and meat quality traits in chickens. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 1, p. 472-482, 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 7. | | FELÍCIO, A. M.; BOSCHIERO, C.; SIVA, N. A.; ANDRADE, J. L. F.; BALIEIRO, J. C.; MICHELAN FILHO, T.; LEDUR, M. C.; COUTINHO, L. L. Polymorphism in the FGFBP1 gene is associated with performance, carcass and meat quality traits in broilers. In: CONGRESSO BRASILEIRO DE GENÉTICA, 57., 2011, Águas de Lindóia. Resumos. Águas de Lindóia: SBG, 2011. p. 213. Projeto/Plano de Ação: 01.06.10602-03.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 8. | | FELÍCIO, A. M.; BOSCHIERO, C.; BALIEIRO, J. C. C.; LEDUR, M. C.; FERRAZ J. B. S.; MOURA, A. S. A. M. T.; COUTINHO, L. L. Polymorphisms in FGFBP1 and FGFBP2 genes associated with carcass and meat quality traits in chickens. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 1, p. 208-222, 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 9. | | OLIVEIRA, G. B.; REGITANO, L. C. de A.; CESAR, A. S. M.; REECY, J. M.; DEGAKI, K. Y.; POLETI, M. D.; FELICIO, A. M.; KOLTES, J. E.; COUTINHO, L. L. Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle. BMC Genomics, v. 19, n. 126, p. 2-16, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 10. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; FRITZ-WATERS, E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, London, v. 17, p. 1-16, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 11. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; WATERS, E. F.; MOURAO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, v. 17, n. 961, p. 1-16, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 11 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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